Effect of varenicline on colonic motility in a rat model of experimental irritable bowel
نویسندگان
چکیده
Aim: We aimed to investigate in vitro effects of varenicline on spontaneous contractile responses of proximal and distal colon smooth muscle in control and IBS rats. Methods: The animal model of IBS-like visceral hypersensitivity was induced by intra-colonic infusion of 0.5% Acetic Acid (AA) in saline once daily between postnatal days 8-21. Control animals received saline instead of AA. Experiments were performed at the end of the 8 weeks. Proximal and distal colon tissues were resected and concentration-dependent effects of varenicline were evaluated in vitro tissue
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